Epinephrine Bitartrate and Lidocaine Hydrochloride Injection Shortage: Availability Updates for Xylocaine

What’s in Shortage

There is a current shortage of Epinephrine Bitartrate and Lidocaine Hydrochloride Injection, commonly known by the brand names XYLOCAINE and XYLOCAINE MPF. This medication is an injection used primarily in Anesthesia and Pediatric therapeutic categories.

The shortage was first posted on October 14, 2016, and the most recent update was provided on February 5, 2026.

Which Manufacturers Are Affected

Fresenius Kabi USA, LLC is the manufacturer currently reporting availability issues for specific presentations. While many versions remain available, several are currently backordered.

Manufacturer Contact: 888-386-1300

Unavailable Presentations:

• Xylocaine, Injection, .01 mg/1 mL; 10 mg/1 mL (NDC 63323-482-17): Next release expected February 2026.
• Xylocaine, Injection, .005 mg/1 mL; 20 mg/1 mL (NDC 63323-489-17): Next release expected February 2026.
• Xylocaine, Injection, .005 mg/1 mL; 10 mg/1 mL (NDC 63323-487-17): Next release expected February 2026.

Available Presentations:

• Xylocaine, Injection, .005 mg/1 mL; 15 mg/1 mL (NDC 63323-488-37)
• Xylocaine, Injection, .005 mg/1 mL; 10 mg/1 mL (NDC 63323-487-37)
• Xylocaine, Injection, .005 mg/1 mL; 15 mg/1 mL (NDC 63323-488-17)
• Xylocaine, Injection, .01 mg/1 mL; 10 mg/1 mL (NDC 63323-482-57)
• Xylocaine, Injection, .01 mg/1 mL; 10 mg/1 mL (NDC 63323-482-27)
• Xylocaine, Injection, .01 mg/1 mL; 20 mg/1 mL (NDC 63323-483-27)
• Xylocaine, Injection, .005 mg/1 mL; 20 mg/1 mL (NDC 63323-489-27)
• Xylocaine, Injection, .01 mg/1 mL; 20 mg/1 mL (NDC 63323-483-57)
• Xylocaine, Injection, .005 mg/1 mL; 5 mg/1 mL (NDC 63323-481-57)

Note: The manufacturer advises checking with wholesalers for current inventory.

Why There’s a Shortage

The source data does not provide a specific reason for the current shortage of these presentations.

What Patients Should Do

If you or a family member are scheduled for a procedure requiring this medication, please consider the following steps:

• Consult Your Healthcare Provider: Discuss the availability of this medication with your doctor or surgeon. They can determine if an available presentation or an alternative treatment is appropriate for your care.
• Speak with Your Pharmacist: Pharmacists often have the most up-to-date information regarding local stock and wholesaler availability.
• Contact the Manufacturer: For specific questions regarding supply timelines, you may contact Fresenius Kabi USA, LLC at 888-386-1300.

Disclaimer: Patients should always consult their healthcare provider regarding medication changes or treatment options.

Source

Information provided by the FDA Drug Shortage Database.