Methotrexate Sodium Injection Shortage: Current Availability and Manufacturer Updates

What’s in Shortage

Methotrexate Sodium Injection (Brand Name: METHOTREXATE) is currently listed in shortage by the FDA. This medication, available in various injection presentations, is primarily used within the therapeutic categories of Oncology and Rheumatology. The shortage status is currently active.

Which Manufacturers Are Affected

Several manufacturers are involved in the supply of Methotrexate Sodium Injection, with varying levels of availability:

• Accord Healthcare Inc.

  • Status: Unavailable
  • Products: Preservative Free, 25 mg/1 mL (NDC 16729-277-30 and 16729-277-35)
  • Contact: 866-941-7875, option 2

• Fresenius Kabi USA, LLC

  • Status: Available
  • Products: 25 mg/1 mL (NDC 63323-123-10) and Preservative Free, 1 g (NDC 63323-122-50)
  • Notes: Patients and providers are advised to check wholesalers for current inventory.
  • Contact: 888-386-1300

• Teva Pharmaceuticals USA, Inc.

  • Status: Available
  • Products: Preservative Free, 25 mg/1 mL (NDC 0703-3678-01, 0703-3675-01, and 0703-3671-01)
  • Contact: 800-545-8800

Why There’s a Shortage

According to the FDA database, the primary reason for this shortage is a shortage of an active ingredient required to manufacture the medication.

What Patients Should Do

If you rely on Methotrexate Sodium Injection for your treatment, please consider the following steps:

• Consult Your Healthcare Provider: Speak with your doctor or specialist immediately to discuss your treatment plan and ensure continuity of care.
• Talk to Your Pharmacist: Pharmacists may have the most up-to-date information on local stock or may be able to source the medication from different wholesalers.
• Contact Manufacturers: You may use the contact information provided above to inquire about specific supply timelines for your region.

Disclaimer: Patients should always consult their healthcare provider before making any changes to their medication or treatment regimen.

Source

Information provided by the FDA Drug Shortage Database. Initial Posting Date: 03/13/2023
Last Updated: 02/03/2026